Product details
Denamarin®, the #1 veterinarian recommended liver support brand*, is a scientifically researched liver health supplement that combines the power of SAMe and silybin to help support healthy liver function.
This product is a hard tablet formulation (not chewable).
Please note: This product is receiving new, updated packaging from the manufacturer; there are no changes to the product itself. Your ordered product may arrive with this updated packaging, depending on manufacturer availability.
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Vet Recommended Liver Support for Dogs and Cats - More veterinarians recommend Denamarin® than any other brand, making it the #1 veterinarian recommended liver support supplement for dogs and cats.*
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SAMe for Dogs and Cats – Denamarin® Advanced for dogs and cats contains proprietary S-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione - the liver’s main detoxifier.
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Better Absorption - The SAMe in Denamarin® Advanced is more bioavailable than original Denamarin® with smaller, easier-to administer-tablets.
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High-Quality Ingredients - In addition to SAMe, the silybin (a bioactive component of milk thistle) found in Denamarin® Advanced is more bioavailable in dogs than standardized milk thistle extract.
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Support Your Pet’s Liver Health - The liver, one of your pet’s most vital organs, is responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system.
Denamarin® Advanced is brought to you by Nutramax Laboratories Veterinary Sciences, Inc., the #1 veterinarian recommended supplement company.† Nutramax has been a leader in pet health for over 30 years, and provides supplements to support joint health, digestive health, skin and coat health, calming, and more.
*Survey conducted among small animal veterinarians who recommended liver support supplements.
†Source: Survey conducted among small animal veterinarians who recommended animal supplements.
Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
For
Dogs and Cats
Ingredients
Each Cats and small dogs tablet contains:
S-Adenosylmethionine 30 mg
Silybin-phosphatidylcholine complex (SPC) 31 mg, providing 9 mg of Silybin A+B
Each Medium dogs tablet contains:
S-Adenosylmethionine 82 mg
Silybin-phosphatidylcholine complex (SPC) 84 mg, providing 24 mg of Silybin A+B
Each Large dogs tablet contains:
S-Adenosylmethionine 172 mg
Silybin-phosphatidylcholine complex (SPC) 123 mg, providing 35 mg of Silybin A+B
Additional (inactive) ingredients are not listed by the manufacturer.
Product class
Dietary supplement, Liver support
Product flavoring
The specific flavoring of Denamarin Advanced Hard Tablets is not provided by the manufacturer.
Manufacturer
Nutramax
Usage
*Please refer to product packaging and label for complete product information, including the manufacturer’s recommended Directions for Use.
Denamarin Advanced Hard Tablets should be given orally as directed by your veterinarian.
Manufacturer suggested usage:
For cats (all sizes) and small dogs (up to 12 lbs): Give 1 Cats/small dogs tablet per day.
For medium dogs (12-34 lbs): Give 1 Medium dogs tablet per day.
For large dogs (35 lbs and over):
35 to 65 lbs: Give 1 Large dogs tablet per day.
66 to 120 lbs: Give 2 Large dogs tablets per day.
Over 120 lbs: Give 3 Large dogs tablets per day.
Denamarin Advanced tablets should be given on an empty stomach, at least one hour before a meal for optimal absorption. For cats, it is suggested that tablets should be followed immediately with a small amount of water to make sure the tablet passes all the way into the stomach. If pilling the dog or cat is not possible, the tablet may be administered with a small amount of food.
The number of tablets administered may be gradually reduced or increased at any time at the recommendation of your veterinarian.
Storage
Store in a cool, dry place at a controlled room temperature and out of direct sunlight. Keep in a secure location out of the reach of children and animals. Keep lid tightly secured to ensure freshness.
Exposure to extreme temperatures or moisture may affect the integrity and effectiveness of medications and supplements. Always store this product properly (e.g., away from the bathroom, kitchen sink, or other damp places).
Side effects
There are no documented side effects reported for this product when given according to the manufacturer’s recommended guidelines.
Please discontinue use and consult your veterinarian if your pet experiences any persistent or troublesome side effects, or if you notice anything unusual.
Precautions
*See product packaging for complete product details including warnings and precautions.
For use in dogs and cats only. Keep out of the reach of children and animals. In case of accidental overdose, contact a health professional immediately.
While there are no documented drug or food interactions associated with this supplement, interactions may still occur. Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Contact your veterinarian if your pet experiences any unusual reactions when multiple medications and/or supplements are given together.
Do not administer this product to animals with a known or suspected allergy or hypersensitivity to it or any of its ingredients. Allergic reactions to medications or supplements may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies to medications or supplements.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this product, please contact the manufacturer Nutramax Laboratories at 888-886-6442 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: this information is for third-party services and is provided for convenience in case of potential poison-related emergencies. There may be consultation fee for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.
Last revised: 12/17/2025