MERCK Animal Health

Incurin® Tablets

MERCK Animal Health
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Incurin® Tablets

Product Information

Incurin® is used for the treatment of hormone-responsive urinary incontinence due to sphincter mechanism incompetence in spayed female dogs. 


Dogs (female)

Generic Name


Brand Names


Drug Class

Estrogen, Hormonal Agent



Product Description & Form

Incurin® 1 mg Tablets 30 ct: 6 mm, white, round (flat with bevelled edges) tablet, scored in half, imprinted with DG;7. (NDC 00061-4323-01)


  • Aids in the management of urinary incontinence and leakage
  • Contains estriol, a naturally occurring, short-acting estrogen found in female dogs with the convenience of once-a-day dosing
  • Estrogens increase the resting muscle tone of the urethra in females and can be used to treat female dogs with urinary incontinence due to estrogen depletion
  • Proven effective in reducing or eliminating urinary incontinence
  • The dose is not dependent upon body weight & is titrated to the lowest effective dose in a step-wise manner

Active Ingredients


Inactive Ingredients

Unspecified source amylopectin, magnesium stearate, potato starch, anhydrous lactose.


Incurin® should be given orally as directed by your veterinarian. Do not stop giving the medication unless advised by your veterinarian. Wash your hands after handling this product.

Missed Doses

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give 2 doses at once.

Side Effects

Side effects may include nausea, swollen teats and vulva. These side effects are expected to minimize after your pet adjusts to the medication. If these symptoms appear excessive or persist, contact your veterinarian. Your pet may also experience (to a lesser degree): anxiety, increased sexual attractiveness, sleepiness/lethargy, or swelling of mammary tissues.

Other side effects may occur, if you notice anything unusual, contact your veterinarian.

Drug & Food Interactions

The following drugs can potentially interact with estriol: cyclosporine, fluconazole, insulin, ketoconazole, levothyroxine, metformin, other estrogens, phenobarbital, theophylline, and ursodiol.  Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. 


Not for use in male dogs. Do not use with other estrogens. The concomitant use of Incurin® with other estrogens has not been evaluated. The concomitant use of Incurin® with glucocorticoids has not been evaluated. The use of Incurin® in dogs with liver disease has not been evaluated. The safe use of Incurin® has not been evaluated in intact female dogs, pregnant or lactating dogs, male dogs, and dogs less than 1 year of age.

Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.

Adverse Reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Merck at 800-224-5318 or Vetsource customer service at 877-738-4443.


Store at or below 77°F in controlled room temperature, excursions permitted to 104°F. Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.

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