Lantus® SoloStar® Pen Insulin

Lantus SoloStar (insulin glargine) is a long-acting insulin containing 100 units/mL (U-100) and is used for the initial treatment and long-term management of diabetes mellitus in dogs and cats.

Dogs and Cats

Insulin glargine

Glycerol 85%, m-cresol, zinc, and Water for Injection, USP.

Hydrochloric acid and sodium hydroxide may be added to adjust the pH.

Lantus SoloStar

Long-acting insulin, Injectable

Sanofi-aventis

This sterile injectable solution contains 100 units of insulin glargine per 1 mL (U-100) of solution and is supplied in a 3 mL prefilled pen device. Please ensure the selected product is appropriate for your pet, as recommended by your veterinarian.

For current availability, please refer to the product selection above.

Lantus SoloStar is intended solely for subcutaneous use (injection under the skin) as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.

Only new, sterile, and compatible pen needles should be used with this product. The use of incompatible or previously used pen needles can result in incorrect dosage, contamination, and/or an increased risk of infection.

Do not use a syringe to remove insulin from your Lantus SoloStar pen.

For general injectable use (aseptic technique):

Aseptic technique refers to a set of practices designed to minimize the risk of contamination and infection during medical procedures. These practices can also be applied to the handling and administration of injectable medications to your pet to help reduce the risk of post-injection bacterial infections.

Wash your hands thoroughly with soap and water before and after administration.

Use a new, sterile pen needle for each injection. Pen needles should never be reused.

Do not touch the pen needle tip or rubber seal of the pen (once it has been wiped with alcohol) to any surface to avoid contamination.

Adequately clean and disinfect the rubber seal of the pen with an alcohol swab, then allow it to dry before attaching the sterile pen needle. Do NOT turn the dose selector knob or press the injection button without a pen needle attached, as this may damage your pen.

Select and administer the prescribed dose as directed by your veterinarian.

Secure the needle using the outer needle cap, then remove the pen needle. Do NOT put the inner needle cap back onto the needle. Exercise proper caution to prevent needlestick injury and risk of cross-infection. Dispose of the used pen needle into a proper sharps disposal container immediately after removal.

Place the pen cap back onto the pen device. Do NOT store the pen device with a pen needle attached.

Administer the dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not administer more medication than prescribed or two doses at once.

If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please consult your veterinarian.

Store new, unopened pens in a refrigerator at a controlled temperature between 36 and 46°F. Unopened pens can be used until the labeled expiration date if they have been stored properly in the refrigerator.

Unopened pens should be thrown away after 28 days if they are stored at room temperature.

Opened, in-use pens should be stored in a cool, dry place at a controlled room temperature (below 86°F). Do NOT put your pen back in the refrigerator after first use.

Only use your pen for up to 28 days after its first use. In-use pens, including any unused remainder, should be thrown away after 28 days (or if the expiration date has passed, whichever comes first).

Do NOT freeze Lantus SoloStar. If a pen has been frozen, it should be thrown away. Protect pens from direct heat and light. Keep Lantus SoloStar and all other medications out of the reach of children and pets.

The most common side effect of insulin therapy is hypoglycemia (low blood sugar). Signs of hypoglycemia may occur suddenly, and may include weakness/lethargy, behavioral changes, muscle twitching, decreased coordination (e.g., stumbling/falling), seizures, and coma.

Always be prepared for an unexpected hypoglycemic event; a source of real sugar (e.g., food, oral dextrose) should be kept on hand and offered to your pet if hypoglycemia occurs. Contact your veterinarian as soon as possible.

Prolonged hyperglycemia can result in severe side effects including seizures, coma, and death. If your pet falls unconscious or has a seizure, this is a medical emergency- seek emergency veterinary attention immediately.

In some cases, injection site reactions (including lumps or thickening of the skin) have been reported. Rotating injection sites may help prevent these reactions.

Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.

If you notice anything unusual, please consult your veterinarian.

Always use a new, sterile, and compatible pen needle for each injection. Using incompatible or previously used pen needles can result in incorrect dosage, contamination, and/or an increased risk of infection.

Do NOT use a syringe to remove Lantus from your SoloStar pen device.

Inspect the pen and insulin solution before each use. Do NOT use if the pen is damaged, if you are not sure that it is working properly, or if the solution has changed in appearance (e.g., color, cloudiness, presence of visible particles). These are signs that the product is no longer fit for use.

For subcutaneous use in animals only. Keep out of the reach of children.

Accidental injection may cause clinical hypoglycemia. In case of accidental injection, seek medical attention immediately. Exposure to this product may induce a local or systemic allergic reaction in sensitized individuals.

Do NOT administer this medication during periods of hypoglycemia. Any change in insulin should be made cautiously and only under a veterinarian's supervision.

Animals presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized.

As with all insulin products, careful patient monitoring for hypoglycemia and hyperglycemia are essential to attain and maintain adequate glycemic control and prevent associated complications.

The safe use of this medication has not been fully established in breeding, pregnant, and lactating animals. Discuss the risks of using this medication with your veterinarian prior to use if your pet is in one of these groups.

Do not administer to animals with a known history or suspected allergy/hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

The following drugs* may have potential interactions with this medication: ACE inhibitors (e.g., benazepril, enalapril), alpha-2 agonists (e.g., clonidine, dexmedetomidine), anabolic steroids, oral antidiabetic agents (e.g., metformin), ARBs (e.g., telmisartan), aspirin, beta agonists (e.g., albuterol), beta blockers (e.g., atenolol, sotalol), corticosteroids (e.g., dexamethasone, prednisone), digoxin, diuretics (e.g., furosemide, hydrochlorothiazide), estrogens (e.g., estriol), fluoroquinolone antibiotics (e.g., ciprofloxacin), concurrent insulins, MAOIs (e.g., amitraz, selegiline), metoclopramide, NSAIDs, pentoxifylline, phenothiazines (e.g., acepromazine), phenylpropanolamine (Proin), progestins (e.g., altrenogest), SGLT2 inhibitors (e.g., bexagliflozin, velagliflozin), SSRIs (e.g., fluoxetine, sertraline), sulfonamides (e.g., sulfadimethoxine, sulfamethoxazole), tetracyclines (e.g., doxycycline), and thyroid hormones (e.g., levothyroxine).

*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.

Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource Pet Owner Care at 877-738-4443.

If you have any reason to suspect an overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

For humans:

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

For animals:

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline® also provides a 24/7 animal poison control service at 855-764-7661.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

Consult your veterinarian for complete information about this product and how it fits into your pet's individual treatment plan.