Novo Nordisk®

Novolin® N Insulin

Novo Nordisk®
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Novolin® N Insulin
Product Information
Novolin® N insulin is an injectable medication that is structurally similar to the insulin produced by the pancreas in humans and is used to control high blood sugar in patients with diabetes mellitus. Multiple types of Insulin exist, so make sure you match the right type of syringe to your Insulin.
Novolin® N Insulin requires refrigeration; all orders must be shipped overnight at an additional charge and are not eligible for free shipping. Orders only ship Monday-Thursday and will not be processed the day before a major holiday.
Generic Name
Isophane Insulin
Brand Names
Novolin® N
Drug Class
Insulin, Intermediate-Acting
Novo Nordisk
Product Description & Form
Novolin® N 100 Units/ml Insulin 10 ml: white and cloudy/milky suspension. (NDC 00169-1834-11)
  • Helps control high blood sugar levels by providing insulin regulation by helping patients properly metabolize sugar
  • Intermediate-acting insulin and starts working 1 & 1/2 hours after injection
  • Greatest blood sugar lowering effect is between 4 and 12 hours after the injection
  • Blood sugar lowering may last up to 24 hours
  • To only be used with U-100 syringes for proper dosing, ask your veterinarian for recommendation
Active Ingredients
Isophane Insulin Human
Inactive Ingredients
Glycerol, metacresol, zinc, phenol, disodium phosphate dihydrate, protamine sulfate, water for injection, hydrochloric acid, sodium hydroxide.
Novolin® N insulin should be administered as directed by your veterinarian. Rotate vial gently in your hands several times until the suspension appears uniformly white and cloudy before use. Your veterinarian will determine the correct dose of insulin need for your pet by means of a blood glucose test. Follow your veterinarian's instructions as doses may vary over time. Refrigeration of in use (open) vials is not required. Use vial within 42 days of first puncture, discard unused portion. 
Injections should be given subcutaneously, just under the skin. Be sure to rotate injection sites to prevent skin problems at the injection site. Pinch a fold in the skin to create a small space for the needle. Insert the needle into the center of the fold as instructed by the veterinarian. Inject the drug by pushing the plunger as far as it will go. Withdraw the needle and be careful to not stick yourself. Dispose the needle immediately in a proper sharps disposal container.  
Insulin syringes and sharps containers are sold separately.  Use only sterile needles/syringes and use each needle/syringe only once.  Injectable medications require needles and syringes.  Those items are purchased separately.  Please ask your veterinarian for a recommendation for the correct needle/syringe sizes for your pet.
Missed Doses
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give 2 doses at once.
Side Effects
Possible side effects of insulin therapy may include hypoglycemia. Signs include hunger, nervousness, vocalization, anxiety, muscle tremors, ataxia, and papillary dilation. If there are signs of hypoglycemia, offer the pet some food or oral dextrose. Positive response should occur within one to two minutes. Prolonged hyperglycemia can result in seizures, coma, and death. Severe hypoglycemic signs require prompt veterinary intervention.
Other side effects may occur. If you notice anything unusual, contact your veterinarian.
Drug & Food Interactions
The following drug interactions that may occur with insulin include: Beta-adrenergic blockers, clonidine, resperidine, and digoxin. Drugs that may increase hypoglycemic activity of insulin (resulting in low blood sugar) include: captopril, enalapril, alcohol, anabolic steroids, beta-adrenergic blockers, MAOI's, guanethidine, phenylbutazone, sulfinpyrazone, sulfonamides, tetracycline, and aspirin, or other salicyclates. Drugs that may decrease hypoglycemic activity of insulin (resulting in high blood sugar) include: epinephrine, estrogen/progesterone combinations, furosemide, glucocorticoids, isoniazide, phenothiazine derivatives, thiazide diuretics, and thyroid hormones. Serum potassium levels can fluctuate in combination with digoxin and insulin and additional monitoring may be needed. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Make sure to tell your veterinarian what other medication or supplements you are giving your pet. Dietary changes may also affect insulin requirements. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. 
This medication does not have an FDA approved indication for use in animals, but it is a common and acceptable practice for veterinarians to prescribe this human medication for use in animals.
Inform your veterinarian prior to use of this medication if your pet has low blood sugar (hypoglycemia). Do not switch from one type insulin to another unless under the direction of a veterinarian as making the switch may require an adjustment in the dose.
Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.
Adverse Reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Vetsource customer service at 877-738-4443.
Store at 36°F to 46°F in the refrigerator. Do not freeze, discard if it has been frozen.
  • Unopened vials stored in the refrigerator are good until expiration date on package.
  • Unopened vials stored at room temperature up to 77°F are good for 42 days.
  • Opened (in-use) vials stored at room temperature up to 77°F are good for 42 days.
Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.
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