MERCK Animal Health

<p>Optimmune® 0.2% Ophthalmic Ointment<br></p>

MERCK Animal Health
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A Chemical on the Prop 65 List


Optimmune® 0.2% Ophthalmic Ointment

Product Information

Optimmune® 0.2% Ophthalmic Ointment is used for management of chronic keratoconjunctivitis sicca (KCS) and chronic superficial keratitis (CSK) in dogs and other eye conditions in dogs.



Generic Name

Cyclosporine, Ophthalmic

Brand Names


Drug Class

Immunosuppressive Agent



Product Description & Form

Optimmune® 0.2% Ophthalmic Ointment 3.5 gm: white ointment. (NDC 00061-1088-01)


  • Believed to act as a local immunomodulator of diseases suspected to be immune-mediated such as keratoconjunctivitis sicca (KCS) and chronic superficial keratitis (CSK)
  • The only FDA-approved veterinary cyclosporine ophthalmic product
  • Achieves therapeutic effect while avoiding systemic toxicity
  • Sterile, preservative-free formulation reduces the chance of secondary infection and chemical irritation
  • Shelf life up to 24 months with no refrigeration

Active Ingredients


Inactive Ingredients

Paraffin, corn oil, petrolatum, lanolin alcohols


Optimmune® should be used as directed by your veterinarian. Administer prescribed dose by pulling down on the bottom lid of your pet’s eye and applying the prescribed amount of ointment into the eye. Exercise proper caution not to touch the dropper or tube opening to any surface including eyes or hands as that may contaminate the sterile surface. Wash hands before and after application.  If using with other eye drops or ointments, separate dosing by 5 minutes.

Side Effects

Side effects may include drowsiness, sedation or unsteady gait. It is possible your pet may experience nausea or loss of appetite when first starting this medication. Notify your veterinarian if these side effects appear, reappear, and/or remain troublesome.

Other side effects may occur, if you notice anything unusual, contact your veterinarian.

Drug & Food Interactions

There are no documented drug interactions with this medication. Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.

Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.


For ophthalmic use in dogs only. The safety of Optimmune® has not been determined in cases of preexisting viral or fungal ocular infections, nor in puppies, pregnant bitches, or dogs used for breeding. In clinical trials, ocular and periocular inflammatory reactions, transient hyperemia, epiphora, mild discomfort of the eye and mild alopecia were reported in a small number of treated dogs.

Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your horse has any known drug sensitivities or allergies. If your horse displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; widespread hives and itching.

Adverse Reactions

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Merck at 800-224-5318 or Vetsource customer service at 877-738-4443.


Store at 36°F to 77°F in controlled room temperature. Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.

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