PRN® Pharmacal

Proin ER™ Tablets

PRN® Pharmacal
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Proin ER™ Tablets
Product Information
Proin ER™ Tablets are indicated for the control of urinary incontinence due to urethral sphincter hypotonus in dogs in a convenient extended release tablets for once a day dosing.
*Proin ER™ is a controlled substance medication in the following states: AR, IA, LA, MS, WV.  All electronically prescribed orders shipping to these states will require verbal authorization with the prescriber prior to dispensing.
*The following states require the pet owner date of birth to be on file prior to dispensing: AR, IN, MS, WV.
Generic Name
Brand Names
Proin ER™
Drug Class
Sympathomimetic, Alpha Adrenergic Stimulant
Product Flavoring
Proin ER™ Tablets are liver flavored.
*Contains yeast, soy, and chicken
PRN Pharmacal
Product Description & Form
Proin ER™ 18 mg Tablets 30 ct & 90 ct: 8 mm, brown, round tablet, not scored, imprinted with 18. (NDC 49427-0344-57, 49427-0344-44)
Proin ER™ 38 mg Tablets 30 ct & 90 ct: 10 mm, brown, round tablet, not scored, imprinted with 38. (NDC 49427-0345-57, 49427-0345-44)
Proin ER™ 74 mg Tablets 30 ct & 90 ct: 12 mm, brown, round tablet, not scored, imprinted with 74. (NDC 49427-0346-57, 49427-0346-44)
Proin ER™ 145 mg Tablets 30 ct & 90 ct: 16 mm, brown, round tablet, not scored, imprinted with 145. (NDC 49427-0347-57, 49427-0347-44)
  • Used to treat dogs unable to hold their urine (urinary incontinence)
  • One extended-release tablet per day can be conveniently given with food
  • Patented extended-release technology provides controlled release that ensures steady absorption
  • Delicious tablets improve compliance and make treatment easy
Active Ingredients
Phenylpropanolamine hydrochloride
Proin ER™ should be given orally as directed by your veterinarian. Proin ER™ should be administered with food. Tablets should not be split or crushed. 
Missed Doses
Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give 2 doses at once.
Side Effects
Your pet may experience vomiting, body weight loss, diarrhea, a loss of appetite, restlessness, irritability, tremors, fast heart rate, high blood pressure and urine retention. If these symptoms appear excessive or persist, contact your veterinarian. If your pet becomes nauseous, loses its appetite, vomits, has a fast heart rate, appears disoriented and the pupils dilate, contact your veterinarian.
Other side effects may occur, if you notice anything unusual, contact your veterinarian.
Drug & Food Interactions
The following drugs can potentially interact with phenylpropanolamine: tricyclic antidepressants, non-steroidal anti-inflammatory agents, halogenated anesthetic agents, ephedrine, chlorpromazine, monoamine oxidase inhibitors, reserpine, and ganglionic blocking agents. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Make sure to tell your veterinarian what other medication or supplements you are giving your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. 
Do not split or crush tablets. For use in dogs only. Not for human use. Keep out of reach of children and pets. The safe use of Proin ER™ in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated.  Proin ER™ may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure.
Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.
Adverse Reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer PRN Pharmacal at 850-476-9462 or Vetsource customer service at 877-738-4443.
Store at 68°F to 77°F in controlled room temperature, excursions permitted between 59°F to 104°F. Keep this medicine out of reach of children. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.
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$25.50 - $52.38