Trusted by veterinarians for over 20 years, Revolution (selamectin) has worked to protect tens of millions of pets and it's an FDA-approved medication that, when applied topically, has systemic effects, treating both internal and external parasites.
FOR KITTENS: Revolution is indicated for the treatment and prevention of flea infestations, ear mites, hookworms and roundworms* and prevention of heartworm disease in kittens 8 weeks and over.
FOR PUPPIES: Revolution is indicated for the treatment and prevention of flea infestations, sarcoptic mange mites, ear mites and ticks** and the prevention of heartworm disease in puppies 6 weeks and over.
Available with a veterinarian prescription only. Ask your vet if Revolution is right for your puppy or kitten. Save with automatic deliveries and enjoy the convenience and peace of mind that your pet doesn't miss a dose.
Revolution contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT).
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Body Weight
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Package color
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Selamectin (per tube)
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Potency
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Volume (per tube)
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|---|
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Up to 5 lbs
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Mauve
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15 mg
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60 mg/mL
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0.25 mL
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Over 5 lbs
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Please refer to the appropriate product (Revolution for Cats or Dogs) corresponding to your pet’s species. If necessary, use the correct combination of tubes to cover your pet’s body weight.
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Please ensure the selected product and quantity are appropriate for your pet, as recommended by your veterinarian. For current availability, please refer to the product selection above.
Usage
Revolution Topical Solution should be administered as directed by your veterinarian. Wash your hands after administration. If the product comes into contact with the skin, wash the area immediately with soap and water. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.
If a dose is missed: apply Revolution immediately to resume monthly dosing and notify your veterinarian. Do not apply two doses at once.
If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule. If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please contact your veterinarian.
Manufacturer Directions for Use*
Always follow your veterinarian's directions. Revolution comes in single-use tubes for easy, monthly administration.
Firmly press the cap down to puncture the seal on the Revolution tube. A clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and make sure the tip of the tube is open.
To administer, part the hair on the back of your cat at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly on to the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty.
Do not massage the product into the skin or apply to broken skin. Additionally, don't apply if your cat's coat is wet. Avoid contact between the product and your fingers. Wash your hands when you have finished applying Revolution to your cat.
*Additional information may be provided within the manufacturer’s full Prescribing Information. Always follow the specific instructions provided by your veterinarian regarding your pet's care.
Storage
Store in a cool, dry place at a controlled temperature below 86°F. Keep this and all other medications in a secure location out of the reach of children and animals. Tubes should remain sealed in their original packaging and should only be opened at the time of dosing.
Exposure to extreme temperatures, light, or moisture can affect the integrity and effectiveness of medications. Always store this medication properly (e.g., away from the bathroom, kitchen sink, or other damp places).
Side effects
For additional information and guidance regarding the potential side effects of this product, please refer to the manufacturer’s full Prescribing Information or consult your veterinarian.
Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product.
The most common side effects of this medication are hair loss at the site of application with or without inflammation (redness, flaking) and gastrointestinal upset.
Contact your veterinarian immediately if your pet has a seizure or experiences tremors, extreme tiredness or weakness, hypersalivation (drooling), or decreased coordination (e.g., stumbling).
The information provided above may not encompass all possible side effects. Please notify your veterinarian if your pet experiences any side effects, including those listed above, or if you notice anything unusual.
Precautions
Before using this product, please review the manufacturer’s full Prescribing Information for any relevant warnings and safety precautions.
For topical veterinary use only.
Not for human use. Keep this and all medications out of reach of children and animals. In case of ingestion by a human, contact a physician immediately.
In humans, Revolution may be irritating to skin and eyes. Reactions such as hives, itching and skin redness have been reported in humans. Individuals with known hypersensitivity to Revolution should use the product with caution or consult a health care professional. If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse the eyes first then remove contact lenses and continue to rinse for 5-10 minutes and seek medical attention.
Flammable - Keep away from heat, sparks, open flames or other sources of ignition.
Do not administer this medication to animals with a known or suspected allergy/hypersensitivity to it or any of its ingredients. Allergic reactions to medications may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies, especially to medications and supplements.
If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.
Drug and food interactions
While there are no documented food or drug interactions reported for this product, potential interactions may still be possible. As with all medications, please consult your veterinarian if you have any questions or concerns prior to use. Contact your veterinarian if your pet experiences any unusual reactions when multiple medications and/or supplements are given together.
Please ensure your veterinarian is aware of all medications, supplements, and over-the-counter (OTC) products that your pet is currently using. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.
Adverse reactions
If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.
Overdose
If you have any reason to suspect accidental consumption or overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.
For humans:
The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.
For animals:
The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.
Pet Poison Helpline also provides a 24/7 animal poison control service at 855-764-7661.
*Please note: The contact information provided above is for third-party services in the event of a potential poison-related emergency. Consultation fees may apply for these services.
Disclaimer
The content provided on this page is NOT medical advice.
All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.
For additional information about this product and how it fits into your pet's individual treatment plan, please consult your veterinarian.
Last revised: 6/12/2026
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