Sileo®

Help stop your dog’s fear and anxiety from frightening sounds with Sileo, the first FDA-approved treatment for dogs that suffer from a serious condition called noise aversion. It is prescribed by your veterinarian to help keep your dog calm when they hear scary noises without making them drowsy, keeping your dog interacting normally with you and your family. Sileo is formulated for situational use, making it the perfect choice for pet owners seeking fast, on-the-spot relief during fireworks, thunderstorms, and other sound-related stressors. Sileo is formulated as a gel that is absorbed into your dog’s body when you apply it between your dog’s cheek and gums and works to calm your dog by preventing or reducing specific reactions in the nervous system.

Do not use SILEO in dogs with severe cardiovascular disease, respiratory, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue or in dogs hypersensitive to dexmedetomidine or to any of the excipients. SILEO should not be administered in the presence of preexisting hypotension, hypoxia, or bradycardia. Do not use in dogs sedated from previous dosing. SILEO has not been evaluated in dogs younger than 16 weeks of age or in dogs with dental or gingival disease that could have an effect on the absorption of SILEO. SILEO has not been evaluated for use in breeding, pregnant, or lactating dogs or for aversion behaviors to thunderstorms. Transient pale mucous membranes at the site of application may occur with SILEO use. Other uncommon adverse reactions included emesis, drowsiness or sedation. Handlers should avoid direct exposure of SILEO to their skin, eyes or mouth. Always review INSTRUCTIONS FOR USE before dispensing and dosing. See full Prescribing Information at SileoDogUS.com.

*SILEO (dexmedetomidine). Prescribing information. Zoetis Inc; 2017.

Dogs

Dexmedetomidine

Alpha-2 adrenoceptor agonist

This product is supplied in 3 mL dosing syringes; each mL of SILEO contains 0.09 mg dexmedetomidine (equivalent to 0.1 mg dexmedetomidine hydrochloride).

Please ensure the selected product and quantity are appropriate for your pet, as recommended by your veterinarian. For current availability, please refer to the product selection above.

Sileo should be administered as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule.

Do not give more medication than prescribed or two doses at once. If you have questions about your pet’s prescribed dosing schedule (e.g., timing, interval), please contact your veterinarian.

Store unopened and opened syringes in the original package at a controlled room temperature (68-77°F) with excursions permitted to 59-86°F. Use syringe contents within 4 weeks after opening the syringe. Keep this and all other medications in a secure location out of the reach of children and animals.

Exposure to extreme temperatures, light, or moisture can affect the integrity and effectiveness of medications. Always store this medication properly (e.g., away from the bathroom, kitchen sink, or other damp places).

Side effects are generally uncommon with Sileo. Transient pale mucous membranes at the site of application may occur with Sileo use. Emesis (vomiting), drowsiness, and sedation have been reported in some cases.

Contact your veterinarian immediately if your pet experiences excessive sedation, collapse, difficulty breathing, excitation/agitation, or if you are unable to wake your animal.

The information provided above may not encompass all possible side effects. Please notify your veterinarian if your pet experiences any side effects, including those listed above, or if you notice anything unusual.

For oromucosal use in dogs only. Sileo is not intended for ingestion and should NOT be swallowed.

Not for human use. Keep out of reach of children and animals.

Avoid administering this product if you are pregnant. Impermeable disposable gloves should be worn when handling the syringe, administering SILEO, or when coming in contact with the dog’s mouth after application.

In case of skin contact, wash with soap and water. Remove contaminated clothing.

SILEO can be absorbed following direct exposure to skin, eyes, or mouth. In case of accidental eye exposure, flush with water for 15 minutes. If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately.

In case of accidental exposure, seek medical attention immediately.

Do not administer this medication to animals with a known or suspected allergy/hypersensitivity to it or any of its ingredients. Allergic reactions to medications may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies, especially to medications and supplements.

If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways; difficulty breathing; agitation; profuse salivation; and widespread hives or itching.

The use of other central nervous system depressants may potentiate the effects of SILEO.

The following drugs* may have potential interactions with this medication: acepromazine (PromAce), antihistamines (e.g., hydroxyzine), beta blockers (e.g., atenolol, sotalol), blood pressure medications (e.g., amlodipine, enalapril, telmisartan), digoxin, gabapentin, methocarbamol, phenobarbital, and tramadol.

*NOTE: This may not be a comprehensive list. As with all medications, please consult your veterinarian if you have any questions or concerns prior to use. Contact your veterinarian if your pet experiences any unusual reactions when multiple medications and/or supplements are given together.

Please ensure your veterinarian is aware of all medications, supplements, and over-the-counter (OTC) products that your pet is currently using. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.

If you are concerned that your pet has experienced an adverse reaction to this medication, please contact Zoetis at 1-888-963-8471 or Vetsource Pet Owner Care at 877-738-4443.

If you have any reason to suspect accidental consumption or overdose, call your doctor/veterinarian or the appropriate poison control resource immediately.

The national toll-free Poison Help line, 1-800-222-1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.

The ASPCA Animal Poison Control Center is available 24 hours a day, 365 days a year at 888-426-4435.

Pet Poison Helpline also provides a 24/7 animal poison control service at 855-764-7661.

All content, including the images and product description above, is intended for general informational purposes only and should not be considered a substitute for professional veterinary consultation, diagnosis, or treatment.

For additional information about this product and how it fits into your pet's individual treatment plan, please consult your veterinarian.