MERCK Animal Health

Tri-Heart® Plus

MERCK Animal Health
Never forget to order with AutoShip 1st order: View schedule
$38.99 - $60.99
This item is currently not available
Optimum Wellness Plan (OWP) Save up to 20% with an Optimum Wellness Plan info icon info icon Help

Members of OWP receive discounts on select online products. Find out more about OWP.

Save 5% with AutoShip info icon info icon Help

Save more when you choose AutoShip. What is AutoShip?

Prescription required Prescription required info icon info icon Help

Before shipping your prescription, we'll require vet approval and verified pet information. You may purchase prescriptions and refills from the pharmacy of your choice.

Log in to your MyBanfield account to continue your purchase.

Don’t have a MyBanfield account? Start one here
Tri-Heart® Plus Chewables for Dogs
Product Information
Tri-Heart® Plus is a chewable, pork flavored tablet administered once a month to protect your dog from the threat of potentially deadly heartworm disease, it also controls against roundworms and hookworms when given every month.
Dogs six months of age and older should be tested for heartworm disease prior to being put on a preventive program and tested annually thereafter. 
Dogs (at least 6 weeks of age)
Generic Name
Ivermectin, Pyrantel Pamoate
Brand Name
Tri-Heart® Plus 
Drug Class
Product Flavoring
Tri-Heart® Plus is an artificial beef flavored chewable tablet.
*Contains pork, soy, and milk.
Product Description & Form
Tri-Heart® Plus Up to 25 lbs: 14 mm, light to dark brown, rectangle, no score/imprint. (NDC 00061-1346-04)
Tri-Heart® Plus 26-50 lbs: 19 mm, light to dark brown, rectangle, no score/imprint. (NDC 00061-1339-03)
Tri-Heart® Plus 51-100 lbs: 24 mm, light to dark brown, rectangle, no score/imprint. (NDC 00061-1353-03)
  • Once a month artificial beef flavored chewable treat that is highly palatable
  • When given at the recommended dose and regimen, Tri-Heart® Plus is effective against the tissue larval stage of heartworm larvae for a month after infection resulting in the prevention of adult heartworms
  • Treats and controls roundworms (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense) once monthly when given routinely
  • Approved for dogs 6+ weeks of age, with no weight requirements
Active Ingredients
Ivermectin, Pyrantel pamoate
Tri-Heart® Plus should be given orally as directed by your veterinarian. This medication should be administered at monthly (every 30 day) intervals, year-round to guarantee protection from heartworms and to treat for roundworms and hookworms.  For dogs over 100 lbs, use the appropriate combination of chewables to ensure complete protection against heartworms.
Remove only 1 chewable at a time from the foil-backed blister card and return the card to the box to protect from light. Do not remove chewable from foil wrapper until you are ready to give it to your dog. Offer to the dog as a treat by hand or in a small amount of dog food. Tri-Heart® Plus can be chewed and or swallowed whole. Make sure entire tablet is consumed. 
Missed Doses
Give the dose as soon as you remember, unless it is time for the next dose. Do not double dose.  If your dog has missed a dose please consult with your veterinarian as testing may be recommended sooner than usual.
Side Effects
Tri-Heart® Plus is generally well tolerated in dogs. There are very few side effects when the drug is given at the usual dose. Ivermectin may cause a shock like reaction in dogs. If this occurs, notify your veterinarian. The following side effects have been reported with the use of Tri-Heart® Plus: depression, lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions, and hypersalivation.  Vomiting has been reported with pyrantel.
Other side effects may occur. If you notice anything unusual, contact your veterinarian.
Drug & Food Interactions
The following drugs can potentially interact with pyrantel pamoate: levamisole, organophospates, diethylcarbamazine, and piperazine.  Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.
Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, and a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your pet more closely.
Certain dogs of the collie breed are more sensitive to the effects of ivermectin.
Heartworm testing should be performed prior to the start of prevention therapy. If the animal is off Tri-Heart® Plus for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result.
Allergic reactions to medications may occur. Be sure to inform VetSource and your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.
Adverse Reaction
If you are concerned that your pet has experienced an adverse reaction to this medication or you have concerns about the product, please contact the manufacturer Merck at 800-224-5318 or contact Vetsource customer service at 877-738-4443.
Store long term at 59°F to 86°F. Store in original packaging to protect from light.  Keep out of reach of children and pets. Store in a childproof container. Store this medicine in a cool, dry place at room temperature. Store away from heat and direct sunlight. Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture.
Sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.
$38.99 - $60.99